Journal of Pharmacology And Experimental Therapeutics Fast Forward First published on April 28, 2005; DOI: 10.1124/jpet.105.084129 0022-3565/05/3142-710-716$20.00
http://jpet.aspetjournals.org/cgi/content/full/314/2/710?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Millar&searchid=1&FIRSTINDEX=0&volume=314&issue=2&resourcetype=HWCIT

Inhibition by PAI-039 of wild-type PAI-1 either purified or in bacterial cell extracts and D95A-PAI-1 in bacterial cell extracts. Purified PAI-1 (PP) and PAI-1 in bacterial cell ...
http://www.jbc.org/cgi/content/full/282/12/9288

Effect of PAI-039 on PAI-1 Secretion by Preadipocytes: Basal and Glucose-Stimulated Conditions Preliminary experiments were performed to determine whether PAI-039 had any cytotoxic ...
http://atvb.ahajournals.org/cgi/content/full/26/10/2209

To investigate, David Crandall, from Wyeth Research in Philadelphia, Pennsylvania, and colleagues assessed the impact that inactivation of PAI-1 by PAI-039 had on adipose tissue ...
http://www.lipidsonline.org/news/article.cfm?aid=3935

The inactivation of plasminogen activator inhibitor-1 (PAI-1) by the small molecule PAI-1 inhibitor PAI-039 (tiplaxtinin) has been investigated using enzymatic analysis, direct ...
http://www.jbc.org/cgi/content/abstract/282/12/9288

Effect of tiplaxtinin (PAI-039), an orally bioavailable PAI-1 antagonist in a rat model of thrombosis.
http://lib.bioinfo.pl/auth:Mugford,C

Objective: We hypothesized that an orally active small molecule inhibitor of PAI-1 (PAI-039; tiplaxtinin) could affect smooth muscle cell (SMC) attachment and migration in vitro on ...
http://www.unboundmedicine.com/medline/ebm/record/17010152/abstract/Effect_of_pharmacologic_PAI_1_inhibition_on_cell_motility_and_tumor_angiogenesis_

... PAI)-1 inhibition protects against renin-angiotensin-aldosterone system-induced cardiovascular injury, the effect of a novel orally active small-molecule PAI-1 inhibitor, PAI-039, was ...
http://atvb.ahajournals.org/cgi/content/full/25/2/365

To investigate, David Crandall, from Wyeth Research in Philadelphia, Pennsylvania, and colleagues assessed the impact that inactivation of PAI-1 by PAI-039 had on adipose tissue ...
http://www.cvspectrum.org/cms/templates/article.aspx?articleid=8924&zoneid=40

To investigate, David Crandall, from Wyeth Research in Philadelphia, Pennsylvania, and colleagues assessed the impact that inactivation of PAI-1 by PAI-039 had on adipose tissue ...
http://client.avee-health.com/NewApollo/cms/templates/article.aspx?articleid=8924&zoneid=40

Tiplaxtinin (PAI-039), a small molecule plasminogen activator inhibitor (PAI)-1 antagonist, exerts an antithrombotic effect in rat models of arterial and venous vascular injury, US ...
http://www.incirculation.net/NewsItem/PAI1-antagonist-prevents-thrombosis-in-rats.aspx?usechannel=

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... PAI)-1 inhibition protects against renin-angiotensin-aldosterone system-induced cardiovascular injury, the effect of a novel orally active small-molecule PAI-1 inhibitor, PAI-039 ...
http://www.tripdatabase.com/spider.html?itemid=388794

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http://www.hopkinsmedicine.org/hse/policies/alphabetical.html

... of PAI-1 in this model by characterizing the effects of L-NAME in wild-type (WT) and PAI-1-/-mice and by administering a novel, orally active PAI-1 antagonist, tiplaxtinin (PAI-039), ...
http://bloodjournal.hematologylibrary.org/cgi/content/full/107/1/132

Tiplaxtinin (PAI-039) is a small molecule inhibitor that is being studied for use in the attenuation of remodeling of blood vessels, a result of arterial hypertension and activation ...
http://en.wikipedia.org/wiki/Plasminogen_activator_inhibitor-1

In human preadipocyte cultures, PAI-039 inhibited both basal and glucose-stimulated increases in active PAI-1 antigen, yet had no effect on PAI-1 mRNA, suggesting a direct ...
http://www.tripdatabase.com/spider.html?itemid=388169

... Collegeville, Pennsylvania, USA; 5 Walker Downey & Associates, Inc., Verona, Wisconsin, USA Summary This study aimed to evaluate a small-molecule PAI-1 inhibitor (PAI-039; tiplaxtinin ...
http://www.schattauer.de/index.php?id=1873&L=1&no_cache=1&tx_ivabonnenten_pi5[download]=1&tx_ivabonnenten_pi5[artikel]=22794

Evaluation of PAI-039 [{1-Benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic Acid], a Novel Plasminogen Activator Inhibitor-1 Inhibitor, in a Canine Model of Coronary ...
http://bloodjournal.hematologylibrary.org/cgi/content/abstract/105/3/1102

Discovery of an orally efficacious inhibitor of coagulation factor Xa which incorporates a neutral P1 ligand. [J Med Chem. 2003] Evaluation of PAI-039 [{1-benzyl-5-[4 ...
http://www.ncbi.nlm.nih.gov/pubmed/15214776